급성기 뇌졸중에서 GABAA α5 길항제에 의한 신경학적 회복과 뇌경색 주변 부위의 재형성 향상
Figure 1. Delayed delivery of S44819 at 10 mg/kg but not 3 mg/kg promotes postischemic recovery of motor coordination deficits. Combined analysis of the exploratory study (animal set 1) and confirmatory study (animal set 4). A, Body weight, (B) laser Doppler flow (LDF) recordings above the middle cerebral artery territory core, and (C and D) coordination skills evaluated by Rotarod and tightrope tests in mice exposed to transient middle cerebral artery occlusion (MCAO). Vehicle or S44819 (3 or 10 mg/kg BID) was administered for 28 d starting 72 h after reperfusion. Body weight (A) and LDF recordings (B) do not differ between groups. Results are means±SD values (n=36 animals per group). *P&li;0.05, ***P&li;0.001 compared with vehicle. Figure 6. S44819 elevates neurotrophic and angiogenic growth factors in the peri-infarct brain tissue. Concentrations of (A) BDNF (brain-derived neurotrophic factor), (B) GDNF (glial cell line-derived neurotrophic factor), (C) FGF (fibroblast growth factor), and (D) VEGF (vascular endothelial growth factor) in peri-infarct striatum and cortex evaluated by ELISA in mice exposed to transient middle cerebral artery occlusion (MCAO) or sham surgery that were treated with vehicle or S44819 (3 or 10 mg/kg BID) starting 72 h after reperfusion. Results are medians (lines inside boxes)/means (crosses inside boxes)±interquartile range (boxes) and minimum/maximum data (elongation lines; n=6 animals per group). *P&li;0.05 compared with ischemic vehicle. Postacute Delivery of GABAA α5 Antagonist Promotes Postischemic Neurological Recovery and Peri-infarct Brain Remodeling Ya-chao Wang,Egor Dzyubenko, Eduardo H. Sanchez-Mendoza, Maryam Sardari, Tayana Silva de Carvalho, Thorsten R. Doeppner, Britta Kaltwasser, Patricia Machado, Christoph Kleinschnitz, Claudio L. Bassetti, and Dirk M. Hermann Stroke. 2018 Oct; 49(10): 2495–2503. |